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A man struggles with memories of his past, including a wife he cannot remember, in a nightmarish world with no sun and run by beings with telekinetic powers who seek the souls of humans.

Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

Ren Amari is the driven inventor of a revolutionary new drug. OtherLife expands the brain's sense of time and creates virtual reality directly in the user's mind. With OtherLife, mere seconds in real life feel like hours or days of exciting adventures. As Ren and her colleagues race around the clock to launch OtherLife, the government muscles in to use the drugs as a radical solution to prison overcrowding. They will create virtual cells where criminals serve long sentences in just minutes of real time. When Ren resists, she finds herself an unwilling guinea pig trapped in a prison cell in her mind. She must escape before she descends into madness, and then regain control of OtherLife before others suffer the same fate.

When Dr. Anthony Edwardes arrives at a Vermont mental hospital to replace the outgoing hospital director, Dr. Constance Peterson, a psychoanalyst, discovers Edwardes is actually an impostor. The man confesses that the real Dr. Edwardes is dead and fears he may have killed him, but cannot recall anything. Dr. Peterson, however is convinced his impostor is innocent of the man's murder, and joins him on a quest to unravel his amnesia through psychoanalysis.

A psychotherapist journeys inside a comatose serial killer in the hopes of saving his latest victim.

Lee Ray Oliver, a death row inmate, is given a second chance at life if he agrees to undergo a new chemical treatment used to modify behavior.