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Charles Dexter Ward, a wealthy scientist, uses an ancient diary and human remains to begin a terrifying and bloody pursuit for immortality.

The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

In 1979, a young girl stumbles upon a possessed tape player. She unknowingly unleashes a demonic entity that haunts her family while slowly dragging the small town of Clarkston to Hell.

After a young couple witnesses a gruesome highway accident, they soon realize they did not leave the crash scene alone, as a demonic presence called the Passenger that won't stop until it claims them both turns their van life adventure into a nightmare.