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The film tells the story of documentary filmmaker Michael King (Shane Johnson), who doesn’t believe in God or the Devil. Following the sudden death of his wife, Michael decides to make his next film about the search for the existence of the supernatural, making himself the center of the experiment – allowing demonologists, necromancers, and various practitioners of the occult to try the deepest and darkest spells and rituals they can find on him – in the hopes that when they fail, he’ll once and for all have proof that religion, spiritualism, and the paranormal are nothing more than myth. But something does happen. An evil and horrifying force has taken over Michael King. And it will not let him go.

A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.

In a dystopian future, the Vatican knows how to resurrect people. A priest discovers a conspiracy behind the resurrections and their possible link to a series of murders.

A woman's hope for a miracle cure turns into a nightmare when she confronts the vengeful spirit of a cursed witch, determined to claim her as a vessel for her evil power.