The Magoichi Saga

With most of his family already dead at Ogami Itto's hands, Retsudo launches one final plot to destroy him, and when that fails, unleashes the fury of every remaining member of the Yagyu clan.

In 1879, Kenshin and his allies face their strongest enemy yet: his former brother-in-law Enishi Yukishiro and his minions, who've vowed their revenge.

Following the death of the second Tokugawa shogun, it is revealed that he was poisoned by retainers of his son Iemitsu in hopes of gaining him the shogunate despite the stammer and birthmark which undermine his respect. Iemitsu and his brother Tadanaga become bitter rivals for the shogunate, and the land is split into factions, eventually erupting into warfare. Iemitsu's mentor, his fencing instructor Yagyu, is fixated upon securing Iemitsu the shogunate and ends up betraying everyone, even his own family, in pursuit of the goal.

Ogami Itto is challenged by a quintet of warriors, each armed with one fifth of Ogami's assassin fee and one fifth of the information he needs to complete his assignment.