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Two women—Diana, a flamboyant and ruthless thief, and Evie, a seemingly innocent young woman with a troubled past—become embroiled in a series of horrific murders on the island of Malta.

Charles Dexter Ward, a wealthy scientist, uses an ancient diary and human remains to begin a terrifying and bloody pursuit for immortality.

On the surface it's believed to be another urban legend - a supernatural being from the afterlife is violently killing anyone who cheats on their significant other in the small college town of Silvercreek, Pennsylvania. But the town's unusually high suicide rate is finally convincing both locals and college students that everything is not as it seems. When Maeve - a female college student - sleeps with Charlie, the married man of the host family she is staying with, both sense the deadly curse is closing in on them. Unable to get anyone to believe them, Maeve and Charlie seek out a local history student to help find answers and figure out a way to defend themselves. It all comes undone, however, as several people are horrifically killed by the savage being - one-by-one at a rapid pace. Eventually, Maeve, Charlie and the few survivors band together in an attempt to defeat the monster once and for all.

When researchers rescue a fellow scientist who survived a meteorite strike in the Arctic, they discover she may not be who they think she is. Is she some-how changed?