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Brooklyn mobster and prolific hit man Jimmy Conlon has seen better days. Longtime best friend of a mob boss, Jimmy is haunted by the sins of his past—as well as a dogged police detective who’s been one step behind Jimmy for 30 years. But when Jimmy’s estranged son becomes a target, Jimmy must make a choice between the crime family he chose and the real family he abandoned long ago. Now, with nowhere safe to turn, Jimmy has just one night to figure out exactly where his loyalties lie and to see if he can finally make things right.

Utah and his girlfriend Opal, are drug addicts living on the streets in rural Ohio. After getting recruited by body broker Wood and offered treatment in Los Angeles, Wood takes Utah under his wing and introduces him to treatment center mogul Vin. Wood and Vin bring Utah in on their lucrative and illegal dealings, where saving lives comes second to the bottom line.

A psychotic man opens fire in a diner, murdering numerous people before killing himself. The survivors struggle in different ways following this horrendous event: a doctor doubts his own instincts and elects to use an experimental medical procedure on his wife, while a gambler believes he's on a lucky streak. A waitress begins engaging in promiscuous sex, and a young girl whose father is among the dead gains unexpected fame.

New York police detective John Shaft arrests Walter Wade Jr. for a racially motivated slaying. But the only eyewitness disappears, and Wade jumps bail for Switzerland. Two years later Wade returns to face trial, confident his money and influence will get him acquitted -- especially since he's paid a drug kingpin to kill the witness.