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Dirty Harry Callahan returns for his final film adventure. Together with his partner Al Quan, he must investigate the systematic murder of prominent figures. By the time Harry learns that the murders are part of a sick game to predict such deaths, it may be too late.

Mason Storm, a 'go it alone' cop, is gunned down at home. The intruders kill his wife, and think they've killed both Mason and his son too. Mason is secretly taken to a hospital where he spends several years in a coma. His son meanwhile is growing up thinking his father is dead. When Mason wakes up, everyone is in danger - himself, his son, his best friend, his nurse - but most of all those who arranged for his death

Brazil is a contract killer, willing to take any job if the price is right. Flint left the assassin game when a ruthless drug dealer’s brutal attack left his wife in a coma. When a contract is put out on the same coldblooded drug dealer, both Brazil and Flint want him dead – one for the money, the other for revenge. With crooked Interpol agents and vicious members of the criminal underworld hot on their trail, these two assassins reluctantly join forces to quickly take out their target before they themselves are terminated.

Raised in Harlem, Tommy Gibbs becomes a successful mob boss but he clashes with the rival Mafia and his old enemy, dirty cop McKinney.