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In the streets of East Los Angeles, Manny is a formidable drug dealer. Impressed by his extravagant lifestyle and prowess, his young son, Kilo, yearns to follow in his footsteps. Kilo resolves to learn how to prosper in the drug world, and his new life as a dealer begins. In a world where a man wants everything, he may end up with nothing.

Young teen girl Xiu Xiu is sent away to a remote corner of the Sichuan steppes for manual labor in 1975 (sending young people to there was a part of Cultural Revolution in China). A year later, she agrees to go to even more remote spot with a Tibetan saddle tramp Lao Jin to learn horse herding.

In the late 1980s, Pat Tate journeys from peddling pills in Marbella to his time in prison, where he solidifies his power before his release to reclaim his turf.

In the fall of 1994, a teacher at Chicago's run-down Steinmetz High conspires with the school's academic decathlon team to cheat on an academic competition.