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Tommy Egan leaves New York behind and plans to take on Chicago, using his outsider status to break all the local rules and rewrite them on his quest to become the biggest drug dealer in the city.

The story of how one company triggered the worst drug epidemic in American history. Look into the epicenter of America's struggle with opioid addiction, from a distressed Virginia mining community, to the hallways of the DEA, and to the opulence of "one percenter" Big Pharma Manhattan.

The arrival of Suzane Von Richthofen shakes Tremembé's order, sparking a power struggle with Elize Matsunaga. Jatobá seeks protection, while Nardoni, the Cravinhos brothers, Roger A. and others face internal clashes and defy the system.

As drugs flood the streets of '90s Britain, a team of civil servants is thrust undercover to topple the gangs behind it.