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Fred, Daphne, Velma, Shaggy, and the talking dog, Scooby-Doo, travel on the Mystery Machine van, in search of weird mysteries to solve.

It's all up to you. You must gather clues, note locations and facts, and finally fit all the clues together to help catch the greatest criminal mastermind in history--none other than the infamous Carmen Sandiego. She's bold, beautiful, and until now, uncatchable. But with your help, the ACME Detective agency might just have a chance at bringing her in.

The gang decide to go traveling in the Mystery Machine, seeking fun and adventure during what could possibly be their last summer break together. However, havoc-wreaking monsters seem to be drawn to them, appearing almost every stop of the way.

This incarnation of the popular cartoon series finds Scooby and the gang living in Crystal Cove, a small town with a long history of ghost sightings, monster tales and other mysteries ripe for the sleuths to solve once and for all. But the longstanding Crystal Cove residents, who bank on the town's reputation to attract tourists, are prepared to do what it takes to protect their turf.