Dragonaut: The Resonance

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.

Humanity has advanced to great heights since it obtained the information technology known as "Mana." With that nearly magical power, problems like war, food shortages, and pollution have been eliminated. In this age of peace and freedom, First Princess Angelise Ikaruga Misurugi of the Misurugi Empire is a privileged girl with no disabilities. She learns, however, that she is a "Norma," a kind of human who cannot use Mana and are outcasts of society. Having lost everything, she is sent to an isolated island. There she meets other Normas who ride in humanoid weapons called Para-mails, protecting the world from dragon invaders from another dimension.