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A U.S. satellite crash-lands near a small town in Utah, unleashing a deadly plague that kills virtually everyone except two survivors, who may provide clues to immunizing the population. As the military attempts to quarantine the area, a team of highly specialized scientists is assembled to find a cure and stop the spread of the alien pathogen, code-named Andromeda.

Raised in a secret facility built for experimenting on children, Jarod is a genius who can master any profession and become anyone he has to be. When he realizes as an adult that he's actually a prisoner and his captors are not as benevolent as he's been told, he breaks out. While trying to find his real identity, Jarod helps those he encounters and tries to avoid the woman sent to retrieve him.

Gary Wallace, a teenager who dreams of beautiful women and a cheerful life, and his only friend, the shy and geek Wyatt Donnelly, always serve as a target for ridicule and bullying of violent classmates. Once using a computer and mysterious electrical radiation, they manage to bring to life the "woman of their dreams." Her name is Lisa, and she is ready to fulfill the wishes of her creators ...

It's been nearly 30 years since Dr. Sam Beckett stepped into the Quantum Leap accelerator and vanished. Now, a new team, led by physicist Ben Song, has been assembled to restart the project in hope of understanding the mysteries behind the machine and the man who created it. Everything changes, however, when Ben makes an unauthorized leap into the past, leaving the team behind to solve the mystery of why he did it.