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Thelma Harper and her spinster sister Fran open their home to Thelma's recently divorced son Vinton and his teenage son and daughter. It's quite an adjustment for everyone, especially the cranky, argumentative Thelma.

Murphy Brown (Candice Bergen) is a recovering alcoholic who returns to the fictional newsmagazine FYI for the first time following a stay at the Betty Ford Clinic residential treatment center. Over 40 and single, she is sharp tongued and hard as nails. In her profession, she is considered one of the boys, having shattered many glass ceilings encountered during her career. Dominating the FYI news magazine, she is portrayed as one of America's hardest-hitting (though not the warmest or more sympathetic) media personalities.

Celebrity pairings ride along in a car together as they sing tunes from their personal playlists and surprise fans who don't expect to see big stars belting out tunes one lane over.

Felix and Oscar are two divorced men. Felix is neat and tidy while Oscar is sloppy and casual. They share a Manhattan apartment, and their different lifestyles inevitably lead to conflicts.