Made in Abyss

Thousands of years after Earth’s atmosphere was destroyed, adventure blooms in the strangest of places. The domed city of Romdo is supposed to be perfect, but Re-l Mayer, a young female inspector from the Civilian Intelligence Office, knows better. In this place where humans and robots coexist, she receives a strange message: something is awakening!

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.

The Diclonius, a mutated homo sapien that is said to be selected by God and will eventually become the destruction of mankind, possesses two horns in their heads, and has a "sixth sense" which gives it telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murder most of the guards in the laboratory, only to get shot in the head as she makes her escape. She survives and manages to drift along to a beach, where two teenagers named Kouta and Yuka discovers her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the evil "Lucy" is not dead just yet...

Oz Vessalius, heir to one of the duke houses, has just turned fifteen. His life is rich and carefree, darkened only by the constant absence of his father. At his coming-of-age ceremony, however, everything changes. For no reason that he can discern, he's cast into the prison known as the "Abyss", only to be saved by a "chain" known as Alice, the bloodstained black rabbit. It is unknown why was he cast into Abyss, how does Alice factor into it all, and what does the organization known as "Pandora" want with him.