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After Neurosurgeon Maggie Sullivan’s personal and professional life are thrown into turmoil she returns home to Sullivan’s Crossing. While there, Maggie is forced to navigate her complicated present while confronting the painful past she has chosen to ignore for years.

Stef Foster, a dedicated police officer, and her partner Lena Adams, a school vice principal, have built a close-knit, loving family with Stef's biological son from a previous marriage, Brandon, and their adopted twins, Mariana and Jesus. Their lives are disrupted in unexpected ways when Lena meets Callie, a hardened teen with an abusive past who has spent her life in and out of foster homes. Lena and Stef welcome Callie and her brother, Jude, into their home thinking it's just for a few weeks, until a more permanent placement can be found. But life has something else in store for the Fosters.

The trials and tribulations of the very large, colorful and imperfect Braverman family.

16-year-old Lux was given up for adoption at birth but never adopted. When she is put back into the custody of her estranged-since-high-school birth parents, Cate and Baze, the three form an unlikely family.