Love, business, anxieties, friendships, feuds, and resentments paint the picture of the main story, that of a group of criminals who for nearly fifteen years, from 1977 to 1992, cherished an illusion: that of conquering Rome. The Lebanese, Freddo, Dandi, Patrizia, and Commissioner Scialoja are some of the characters inspired by the true story of the Magliana gang. As stated by Aldo Grasso, the first season of the series gives more space to the crime scene, that is, the criminal exploits of the Magliana gang, while the second season delves deeper into the "behind the scenes" of the crime: thus, the gang's repositioning after a key plot event, and the effects and questions this has provoked in the protagonists' consciences.

According to an ancient legend of the Sicilian tradition, the Natives are a lineage of fascinating women endowed with extraordinary powers, whose spirits manage to separate from their bodies to torment and ruin the lives of the unfortunate victims of the moment. The one who feels persecuted by a Native is Michela, a young doctor who, after returning to her small hometown on the slopes of Etna, witnesses a progressive derailment of her professional and emotional life. Paranoid and suspicious of everyone, Michela needs to identify who her enemy is among the many women around her and face her head on before it's too late.