According to an ancient legend of the Sicilian tradition, the Natives are a lineage of fascinating women endowed with extraordinary powers, whose spirits manage to separate from their bodies to torment and ruin the lives of the unfortunate victims of the moment. The one who feels persecuted by a Native is Michela, a young doctor who, after returning to her small hometown on the slopes of Etna, witnesses a progressive derailment of her professional and emotional life. Paranoid and suspicious of everyone, Michela needs to identify who her enemy is among the many women around her and face her head on before it's too late.

Trevor McNills suffers from an obsessive-compulsive personality disorder: he is an important businessman with the mania to control everything, even the lives of his employees. Fascinated by the beauty of his young employee Natalie, Trevor will begin to make the girl's life a hell, turning the attraction for her into a real obsession.