The animated buddy movie follows the misadventures of Don, a runaway puppet with boundless imaginations, and DJ Doggy Dog, an abandoned plush looking for a friend, who cross paths in Central Park and team up against all odds for a epic friendship adventure in New York.

Four tuxedo clad men show up at a penitentiary to meet a friend who has just been released after three years in prison and is going straight from the jail to marry his girlfriend. En route to the wedding, one of the men asks to stop by a bank to pick up some cash. As it turns out, he is a wanted bank robber who uses Shakespeare passages during his robberies and thus has become known as "Hamlet". Soon all five men are caught up in the bank and involved in the robbery as they end up in a hostage situation. The hostage negotiator shows up who turns out to be Hamlet's father.