It's autumn in New York. Sam has broken up with his girlfriend and his father has recently died. World-weary and sloppy drunk, he finds temporary solace in the arms of Anna, a mysterious vampire who draws him away from his friends and into a web of addiction and madness.

Coco Dupree is a New York performance artist who makes a living dancing topless in a bar. There she meets a mob boss who calls himself God, a thug named Richie, and a kept woman named Desiree.

The Age of Insects follows the metamorphosis of a young delinquent forced by his parents to undergo dubious "orthopodization" treatments from an insect-obsessed doctor.