Terrence McDonagh is a New Orleans Police sergeant, who receives a medal and a promotion to lieutenant for heroism during Hurricane Katrina. Due to his heroic act, McDonagh injures his back and becomes addicted to prescription pain medication. He then finds himself involved with a drug dealer who is suspected of murdering a family of African immigrants.

In the Texas bayous, a local homicide detective teams up with a cop from New York City to investigate a series of unsolved murders.