Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

New York mafia capo Dwight "The General" Manfredi is released from prison after 25 years and exiled by his boss to set up shop in Tulsa, Oklahoma. Realizing that his mob family may not have his best interests in mind, Dwight slowly builds a crew.

Hotshot plastic surgeons Dr. Sean McNamara and Dr. Christian Troy experience full-blown midlife crises as they confront career, family and romance problems.

Doogie Howser is a doctor. He is also a 16-year-old genius who graduated college at age 10 and finished medical school at age 14. But he is still a teenager, with normal teenage friends and problems. But unlike a normal teenager, he is just learning to drive while also consulting on serious medical cases like heart transplants.

Special Agent Simone Clark, the oldest rookie in the FBI, is a force of nature, the living embodiment of a dream deferred – and she works together with her new colleagues at the Los Angeles office of the Bureau to bring down the country’s toughest criminals.

By 2017, the global economy has collapsed and U.S. society has become a totalitarian police state, censoring all cultural activity. The government pacifies the populace by broadcasting a number of game shows in which convicted criminals fight for their lives, including the gladiator-style The Running Man, hosted by the ruthless Damon Killian, where “runners” attempt to evade “stalkers” and certain death for a chance to be pardoned and set free.

Following a bomb scare in the 1960s that locked the Webbers into their bomb shelter for 35 years, Adam now ventures forth into Los Angeles to obtain food and supplies for his family, and a non-mutant wife for himself.

After a comet disrupts the rain cycle of Earth, the planet has become a desolate, barren desert by the year 2033. With resources scarce, Kesslee, head of the powerful and evil Water & Power Corporation, the de facto government, has taken control of the water supply. Unwilling to cower under Kesslee's tyrannical rule, a pair of outlaws known as Tank Girl and Jet Girl rise up, joining the mysterious rebel Rippers to destroy the corrupt system.

Mickey Gordon is a basketball referee who travels to France to bury his father. Ellen Andrews is an American living in Paris who works for the airline he flies on. They meet and fall in love, but their relationship goes through many difficult patches.

A "rockumentary", covering the rise to fame of MC Gusto, Stab Master Arson, and Dead Mike: members of the rap group "CB4". We soon learn that these three are not what they seem and don't appear to know as much about rap music as they claim... but a lack of musical ability in an artist never hurts sales, does it? You've just got to play the part of a rap star...

Matt and George investigate a series of strange occurrences involving newcomers, who are found to be programmed to carry out someone's dirty work. The method by which they are brainwashed dates back to the slave ship's rebellion group, the Udara, who, we discover, Susan was a part of. Susan and George's lives are further disrupted when Buck enrols in the police academy.