Mitch Buchannon, believed to have died in a boating accident survived and only has amnesia, he has been recovering in a Los Angeles hospital. His new fiancée, Allison Ford, resembles his old lover, Lt. Stephanie Holden who died years ago.

A psychology student invites a group of his friends and teacher to a drug and alcohol-fueled party where he plans to murder them all.

It has been 73 years since Alex failed and the Humans lost the Cyborg Wars. Since then, the Humans have been enslaved. Scientists have developed a new DNA strain, which could signal the end of the Cyborgs, and they inject it into a volunteer. When the Cyborgs learn of the woman and the baby they list both for termination.

In this wasteland of despair the path to redemption is not clear. But Alex – a mutant created with super human DNA – carries the seed of hope for all mankind. In a struggle for domination that will never end, the Cyborg enemy – designed by humans as weapons without a soul – will not stop until this divine spark of humanity is eliminated. The Cyborgs are back, here and now, and stronger than ever. The terror has returned and we must face what they bring…

"First Strike" pilots have the mission of destroying nuclear arms that have fallen into the hands of bandits.