A mentally ill man in a small Texas town goes on a killing rampage and is fatally wounded by police. When doctors use an experimental serum to bring him back to life, the killer develops superhuman strength and the town sheriff must pursue him.

Zack, a young boy, finds two Cocker Spaniels caged in the woods and takes them home. The animals, Sissy and Buddy, have magical healing powers that change the people of a small town.