An imaginative elephant named Horton hears a faint cry for help coming from a tiny speck of dust floating through the air. Horton suspects there may be life on that speck and despite a surrounding community, who thinks he has lost his mind, he is determined to save the tiny particle.

Wilbur the pig is scared of the end of the season, because he knows that come that time, he will end up on the dinner table. He hatches a plan with Charlotte, a spider that lives in his pen, to ensure that this will never happen.

An aspiring teenage filmmaker gets hired by a production company to make sketch comedy for teens.