Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.

Mallory is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava, an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina; and an armed governmental agent named Durand.