A deadly virus threatens to wipe out an entire Rocky Mountain town, leaving the town doctor to find some way to escape the soldiers who enforce the town's quarantine and devise an antidote. Matters take a more deadly turn after the physician is captured by a dangerously unstable band of militia extremists.

The year is 1955, and a great flood is coming to Northfork, Montana. A new hydroelectric dam is about to be installed in the mountains above the town, ready to submerge the valley in the name of progress. It is the responsibility of a six-man Evacuation Committee to relocate the townsfolk to higher ground. Most have duly departed, but a few stubborn stragglers remain – among them a priest caring for a sickly orphan, a boy whose fevered visions are leading him to believe he is a member of a roaming band of lost angels desperately searching for a way home.

Henry Hart is a young gay artist living in New York City. When his grandfather has a stroke, Henry puts his career on hold and returns home to the small town of Big Eden, Montana, to care for him. While there, Henry hopes to strike up a romance with Dean Stewart, his high-school best friend for whom he still has feelings. But he's surprised when he finds that Pike, a quiet Native American who owns the local general store, may have a crush on him.

When Sean's macabre work begins selling from her art gallery walls, Lacy decides to meet this new up and coming artist in his small Montana town . While there, Lacy discovers the horrible answer to a town mystery and the true inspiration of Sean's work.