Thanks to a Japanese scientist's invention of synthetic blood, vampires have progressed overnight from legendary monsters to fellow citizens. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides. But in the small Louisiana town of Bon Temps, the jury is still out.

Xena is an infamous warrior on a quest to seek redemption for her past sins against the innocent. Accompanied by her comrade-in-arms Gabrielle, the campy couple use their formidable fighting skills to help those who are unable to defend themselves.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

Cryptozoologist Doctor Peña traps the legendary Chupacabra on a remote Caribbean Island to make his name in the scientific community. When he smuggles it aboard the cruise ship Regent Queen, commanded by Captain Randolph, the monster breaks out of the cargo hold and makes a smorgasbord out of the passengers and crew.