Sidika is the story of Saka family and their young daughter Sidika who live in a poor neighborhood of Istanbul. Sidika was not allowed to go to high school, raised to wait her husband-to-be at her fathers home, not even allowed to leave their house on her own. But she educated herself through books, newspapers and TV. She approaches her life, half-witted older brother, oppressive and alcoholic father and traditionalist mother in a satirical and fun manner along with the current political and sociological events of Turkey and the world. She gazes the world through her window as she hungers for all the intellectual accumulation of the universe.

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Salih is a mechanic and the son of a respected barber named Ali. A woman named Tina arrives at Cholera Street, where she takes up residence and works as a prostitute.