The stripper Rachel is hit by a cab but survives in the emergency room of a hospital. However, she sees Death chasing her, but she does not succeed in convincing the nurses. She is drugged and wakes up in St. Joseph, a mental hospital administrated by Dr. Brown. She finds five other inmates that had a near death experience and also claim that Death is coming for them.

Wry, cynical and full of off-beat humor, 'Apocalypse, CA' is the story of friends as they prepare for certain death at the hands of a massive asteroid, sex-inducing drugs, a three-hundred foot giant, and a horde of other absurd problems.