The sleepy Pacific Northwest town of Eureka is hiding a mysterious secret. The government has been relocating the world's geniuses and their families to this rustic town for years where innovation and chaos have lived hand in hand. U.S. Marshal Jack Carter stumbles upon this odd town after wrecking his car and becoming stranded there. When the denizens of the town unleash an unknown scientific creation, Carter jumps in to try to restore order and consequently learns of one of the country's best kept secrets.

Dr. Burke Ryan is a successful self-help author and motivational speaker with a secret. While he helps thousands of people cope with tragedy and personal loss, he secretly is unable to overcome the death of his late wife. It's not until Burke meets a fiercely independent florist named Eloise that he is forced to face his past and overcome his demons.

Dr. Taylor Biggs is haunted by a past that's not his own. A hallucinatory drug gives him the power to see visions of vicious crimes, visions made all that more disturbing when he discovers that the murderous memories may belong to the father he never knew . Biggs's mother, whose own failing memory makes her powerless to help him unravel his family history.