In this bizarre character study/satire of the Cafe Cino/La Mama/Andy Warhol subculture, Dewey is a young actor/hustler who has just had sex with an older actress, Miss Gloria, who talks about her lifestyle as a 'compass rose'. After Dewey leaves, Gloria has over some 'medical doctors' who give her 'medication' involving a blood transfusion. Dewey returns home where his girlfriend, Olive, arrives and shows off some of her latest wardrobe and plays around with him, despite his lack of interest in her. Dewey phones his hippy friend Allen, also a struggling actor and sells drugs on the side hoping to finance his first directing gig. Meanwhile, Brandex, another bare-chested actor, flirts with Cathy, a dimwitted actress/stoner who debates which blouse to wear for the upcoming show.

An angry, alcoholic matriarch tyrannizes her spoiled, adult children during an unwanted family meeting, where someone begins killing them one by one.