Young scout Breck Coleman leads a wagon train along the dangerous trail to Oregon as he tries to get the affection of the beautiful pioneer Ruth Cameron and plans his revenge on the harsh scoundrels who murdered a friend of his in the past.

The first part tells the story of Moses leading the Jews from Egypt to the Promised Land, his receipt of the tablets and the worship of the golden calf. The second part shows the efficacy of the commandments in modern life through a story set in San Francisco. Two brothers, rivals for the love of Mary, also come into conflict when John discovers Dan used shoddy materials to construct a cathedral.

Brandon, a surveyor, dreams of building a railway to the west. He sets off with his son, Davy, to survey a route. They discover a new pass which will shave 200 miles off the expected distance, but they are set upon by a party of Cheyenne. One of them, a white renegade with only two fingers on his right hand, kills Brandon and scalps him. Davy is all alone now.

Salomy Jane, a California mountain girl, is sought after by a number of men in the nearby small town of Redwood City. She is affected when two criminals are pursued by authorities: one for killing a hypocritical mayoral candidate, the other for robbing the stagecoach.

A crooked real estate manipulator sells worthless land on mortgage to flood refugees, then tries to profit by reselling the land to the state, committing murder in the process, as the Three Mesquiteers work to bring him and his gang to justice.

In 1877, thieves Ace Beaudry, Bronco Dawson and Bull Stanley head West together after having each been betrayed by a woman. They come across a wagon train bound for the town of Custer, where hundreds of people are gathering for a land rush in the Dakotas, which President Ulysses S. Grant has opened to settlers thanks to a treaty with the Sioux Indians. After the three rogues ride off, they spy a lone wagon with a tempting string of thoroughbreds. Before they can steal the horses, however, the wagon is attacked by a gang led by Layne Hunter, a shifty saloon owner from Custer. The trio chase off the gang, and as they are about to abscond with the horses, they find pretty Lee Carleton, whose father was killed in the attack.

A dog named Thunder, the weakling of his brood, is born in a lumber camp in the North Woods, operated by Anita Baker. The cowardly dog is cast out of the camp and adopted by forest ranger Allen Gregory. Meanwhile, Bill Martin, the brutal camp superintendent, covets both Anita and her property. When Bill attacks Anita, Thunder comes to the rescue and proves his courage by warding off the villain.

A Texas Ranger insinuates himself into a murderous gang by showing off his talents. When he is taken prisoner by the ringleader, he makes a getaway and returns with a sheriff.