Follow the lives of a group of young adults living in a brownstone apartment complex on Melrose Place, in Los Angeles, California.

Steve Brooks, a sexist womanizer, is killed by a group of his angry former lovers. In heaven, he makes a bargain with God for redemption and agrees to return to Earth. Once there, he must have a sincere relationship with a female and make her fall in love with him. If not, Steve's soul will become the property of the devil. But the devil hedges his bet, and Steve is reincarnated as a woman named Amanda Brooks.

Lukas Armand, a skull-faced movie producer, is auditioning lovely young starlets for his upcoming low-budget horror pic. The girls are delighted to learn they've been chosen to star in the film until Lukas' creepy gofers; Jason and Mad-dog kidnap the actresses, one by one and lock the terrified girls somewhere in the bowels of the film studio.

Three women on vacation in a mountain cabin are terrorized by two psychopaths.

At the Tromaville Institute of Technology's nuclear plant, Prof. Holt has perfected "subhumanoids": living beings without emotions who perform menial tasks. When school reporter Roger Smith meets a beautiful subhumanoid named Victoria, they fall in love and he becomes determined to save her and the school from a giant mutant squirrel, Tromie.

Gena is an average woman who is torn between her current boyfriend's desire to marry her and start a family, and the unexpected arrival of an old boyfriend wanting to pick up where they left off. To further complicate matters, she might be pregnant herself. In the mist of this unsettled personal life, Gena leaves her two men to attend a baby shower party for a girl friend and talks with the various female attendees all of whom are facing their own ticking biological clocks.

Martin is a total loser, who nobody cares for. When he fails to get a position as guitar player in Lindsay's band and loses his job on the way, he makes a deal with a Voodoo priestess. She promises him the fulfillment of all his dreams if he swears obedience to her. He becomes a rock star and has many women - but to stay alive, he has to kill other people.

Two detectives are out to nail a gang of teenagers who have run wild through the city and brutally raped a woman.