After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.

A younger sister wishes to switch places with her popular older sister and the two bickering siblings awaken to find the wish has come true.

129 ordinary people dare to achieve the extraordinary on a 314-mile journey across the state of Tennessee, relying solely on local Volunteer State communities for aid.