As America's stock of athletic young men is depleted during World War II, a professional all-female baseball league springs up in the Midwest, funded by publicity-hungry candy maker Walter Harvey. Competitive sisters Dottie Hinson and Kit Keller spar with each other, scout Ernie Capadino and grumpy has-been coach Jimmy Dugan on their way to fame.

Max Baron is a Jewish advertising executive in his 20s who's still getting over the death of his wife. Nora Baker is a 40-something diner waitress who enjoys the wilder side of life. Mismatched or not, their attraction is instant and smoldering. With time, however, their class and age differences become an obstacle in their relationship, especially since Max can't keep Nora a secret from his Jewish friends and upper-crust associates forever.

When Dr. Marcus Sommers realizes that he and his troubled, estranged brother David may be prone a fatal brain disease that runs in their family, he decides to make peace with his sibling, and invites him on a trip to the Rockies. There, the brothers bond over their shared enthusiasm for cycling and decide to enter a grueling bike race through the mountains. However, Marcus' health soon begins to fail, and David must compete without his brother at his side.

A divorce lawyer is kidnapped by several disgruntled past clients and forced to fight a series of people in the back room of a tile store in St. Louis.