Revolves around married English couple named Bob and Margaret Fish, a middle class 40-ish working couple with no children and two dogs named William and Elizabeth. Bob is a dentist and Margaret is a chiropodist. Bob and Margaret struggle with everyday issues and mid life crisis. Stories often revolve around the mundane, but in a way which is eminently relatable. In the first two seasons, Bob and Margaret live in England, in the South London community of Balham. For the third and fourth seasons, they move to Toronto, Canada, allowing the writers to explore the humour of the culture clash.

Five animals meet regularly to discuss their inner angst in a group therapy session led by Dr. Clement, a canine psychotherapist. The group includes Lorraine, a leech who suffers from separation anxiety; Cheryl, a praying mantis who can’t seem to keep a man; Todd, a pig with an eating disorder; Jeffrey, a bird with guilt issues; and Linda, an obsessive-compulsive cat.

Margaret Fish is planning a surprise party for her dentist husband, Bob. Meanwhile, at the office, Bob is having a mid-life crisis while insects munch on what's left of his plants. When Bob returns home, Margaret has a terrible time getting him into the room where everyone's hidden until he's halfway through changing clothes and talking about how horrid all their nebbishy friends are (the same friends hidden all over the room).