Two friends, both named Frank, accidentally obtain a suitcase at the airport. It contains incriminating evidence against a mafia boss, who sends his Terminator-like lackie to find them. The Franks hide by impersonating make-up women for a beauty pageant. While in drag, the mafioso falls in love with one of the Franks.

A solar eclipse seems to be interfering with the menstrual cycle of women everywhere and wreaking havoc on their hormones. The result is a need to kill any and every man they see. Some women fight it, and some sink into it like a comfy couch. By the time the film is done, the body count is high, lots of blood has been spilled, and women everywhere become murder machines.