After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

The show follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

The Philadelphia homicide squad's lone female detective finds her calling when she is assigned cases that have never been solved. Detective Lilly Rush combines her natural instincts with the updated technology available today to bring about justice for all the victims she can.

Mick St. John is a captivating, charming and immortal private investigator from Los Angeles, who defies the traditional blood-sucking norms of his vampire tendencies by using his wit and powerful supernatural abilities to help the living.

Reflects the injustices of a painful chapter of American History, while honoring the 50th anniversary (July 2, 1964) of the Civil Rights Act abolishing segregation.