The Naked Brothers Band is an American musical comedy series created by Polly Draper. The show depicts the daily lives of Draper's sons, who lead a fictional world-renowned rock band from New York City. As a mockumentary, the storyline is a hyperbole of their real lives, and the fictional presence of a camera is often acknowledged. Lead vocals and instrumentation are provided by the siblings; they wrote the lyrics themselves. The show stars Nat Wolff and Alex Wolff, who encounter conflicts with each other that are later omitted. Nat's fictional female admirer and real life preschool friends—including the guitarist who had no prior acquaintance with the family—feature as the band members, with the siblings' genuine father and Draper's husband as their accordion-playing dad and Draper's niece as the group's babysitter. The series is a spin-off of Draper's 2005 film of the same name that was picked up by Nickelodeon, premiering in January 2007. Draper, star of Thirtysomething and her writings The Tic Code and Getting Into Heaven, is the executive producer of the series, and often writer and director. Albie Hecht, affiliated with Nickelodeon and founder of Spike TV, is the executive producer, under his Worldwide Biggies tag. Draper's husband Michael Wolff, of The Arsenio Hall Show fame, serves as the music supervisor and co-executive producer with Draper's brother Tim as the consulting producer.

Desperate for a breakthrough as she nears the big 4-0, struggling New York City playwright Radha finds inspiration by reinventing herself as a rapper.

Rosalina comes back after her music cruise, but Michel (the French guy Rosalina kissed on the cruise) also comes back, criticizes Nat's music, and kisses Rosalina which Nat sees. This causes a heated fight between Nat and Rosalina in which they break up and Rosalina quits the band.

The band's next concert stop is in New Orleans where Nat reunites with a childhood friend, sending Rosalina into a jealous frenzy! Meanwhile, Alex initiates an extreme environmental movement to help save polar bears at the North Pole, but devious reporters frame him to appear as a conceited rock star who hates Santa!

The Naked Brothers Band and another band, the L.A. Surfers, find themselves competing in a "Battle of the Bands" charity event benefiting Little Kids Rock. Rosalina starts to fall for the L.A. Surfers' lead singer, Bobby Love. It annoys Nat that Rosalina hangs out with the opponent's lead singer. It turns out that Bobby is just dating Rosalina to get to Nat and is lying about everything, i.e, his British accent, not writing his own songs, etc. Nat and Bobby fight and declare at a press conference that the charity event is now a competition and the losing band's proceeds from their next CD goes to the charity.

A man, after being robbed and shot fourteen years earlier, succumbs to a life of addiction and ultimately loses the love of his life and knowing his only child. After meeting a local pastor, Brian is forced to confront his alcohol addiction. His volunteer work at the pastor's church leads him to a job as a home health-care worker. Upon meeting his first patient, Taj, the two men are unaware that their lives will forever be changed through this trying relationship.