A late-night live television sketch comedy and variety show created by Lorne Michaels. The show's comedy sketches, which parody contemporary culture and politics, are performed by a large and varying cast of repertory and newer cast members. Each episode is hosted by a celebrity guest, who usually delivers an opening monologue and performs in sketches with the cast, and features performances by a musical guest.

Stepping into the late-late slot vacated by David Letterman, Conan O'Brien stars in a show that far outdoes its competition in sheer strangeness. Along with the celebrity interviews and musical numbers typical of late-night talk shows, this program make frequent use of odd walk-on characters and frequent "visits" from celebrity guests.

In the 1960s, Reverend Jim Jones began as an idealist helping minorities and working against racism. After a move to San Francisco and increased power and attention, Jones became focused on his belief in nuclear holocaust, declared himself a prophet, and founded the Peoples Temple. With a loyal following of over 1,000, who donated their entire life savings to him and to join his commune, he moves them to Guyana. When possible crimes come to the attention of the authorities, and once notified that some individuals are being held against their will, an investigation begins. Rather than face the charges, Jones commits suicide, and roughly 900 of his followers do the same.

Conan O'Brien celebrates ten years of "Late Night with Conan O'Brien" in this one-hour special. Many guest appearances and clip montages show us how funny his show has been.