The program follows four modern day explorers—a navigator, a wildlife expert, a survivalist, and a journalist—as they substantially retrace H.M. Stanley's famed expedition to find Dr. David Livingstone. Their route deviates somewhat from Stanley's in that it includes a treacherous crossing of the Uluguru Mountains, which Stanley circumvented.

Filmed in IMAX, a team of explorers led by Pasquale Scaturro and Gordon Brown face seemingly insurmountable challenges as they make their way along all 3,260 miles of the world's longest and deadliest river to become the first in history to complete a full descent of the Blue Nile from source to sea.