Disregard for alchemy’s laws ripped half of Edward Elric’s limbs from his body and left his brother Alphonse’s soul clinging to a suit of armor. To restore what was lost, the brothers seek the Philosopher’s Stone. Enemies and allies – the corrupt military, the Homunculi, and foreign alchemists – will alter the Elric brothers course, but their purpose will remain unchanged and their bond unbreakable.

Chihaya Ayase has spent most of her life supporting her sister’s model career. When she meets a boy named Arata Wataya, he thinks Chihaya has potential to become a great karuta player. As Chihaya dreams of becoming Japan's best karuta player, she is soon separated from her karuta playing friends. Now in high school, Chihaya still plays karuta in the hope that she will one day meet her friends again.

Amamizukan is an apartment complex where no boys are allowed. Tsukimi, a girl who adores jellyfish, lives there happily with her friends who all have nerdy obsessions of their own. Their peaceful lives gradually start to change when a beautiful woman helps Tsukimi out of a pinch. She stays overnight at the apartments—but it turns out "she" is really a "he".

Fumi Manjoume enters Kamakura's accelerated high school - Matsuoka All-Girls High School. While waiting at the Kamakura station on the day of her entrance ceremony, she runs into an old childhood friend whom she had not seen in 10 years: Akira Okudaira. As their friendship is rekindled and they start falling back into the rhythm of friends again, it starts a delicate love story...

Inspector Zenigata pursues Lupin as the prime suspect behind a terrorist attack. But when he manages to confront the famous thief, he quickly deduces that the bomber is a second, fake Lupin. Now, it's up to Zenigata to capture both Lupins and solve the mystery behind the bombing.