Gotham Comedy Club, a popular comedy venue in the Chelsea neighborhood of Manhattan, is the setting of an hourlong series that is shot in front of an audience at the club. Each episode features routines by several comics -- a list that has included such names as David Alan Grier, Gilbert Gottfried and Artie Lange -- in what the network says is an unedited and uncensored format. In addition to the big names of the field who take the Gotham stage, the show also features up-and-comers who want to make a name for themselves in the stand-up comedy business.

Amy is having the worst day of her life. Her 16-year-old daughter, Emma, is finally undergoing a heart transplant after waiting over two years. As Emma fights for her life, Amy sits alone in the hospital waiting room, overwhelmed by fear, exhaustion, and a deep anger towards God. She tries to pray but can’t find the words, consumed by rage at the unfairness of it all.

Walt (lover of threesomes, hater of shirts) strikes up an unlikely friendship with a former Pro Bowler as they discover he might be THE GOAT of the lanes. The only things standing in their way are racism, alcoholism and Linda "The Crusher" Curson.

Carrie's life is at a standstill. She's fed up of being a social outcast. Then one day, she stumbles across a magic lamp. Out of the lamp appears Jeanie. An 8th century Macedonian prostitute! Life will never be the same for Carrie, as Jeanie allows her to have 10 wishes, and to make wishes that she wants.

Six teenagers on a boat trip get lost in parallel dimensions where they are forced to face their greatest fears.

When a suburban housewife discovers that her husband has become a Zombie with an appetite for human flesh, she fights to keep him well fed and out of government clutches.

Three nuns about to renounce God are recruited by an agency within the church to masquerade as prostitutes in order to bring down a sex trafficking organization.