In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.

Starstruck Indiana small-town girl Lily is pestering theatrical producer John Thornway for a role but he is reluctant.

Gambling boat operator Jenny Blake throws over her gambler beau Jack Morgan in order to marry into high society.

A shrewd millionaire who owns races horses for publicity for his automobile business, claims ownership of a female horse trainer's thoroughbred in order to get the trainer.

Carrie Snyder is a prostitute, who is forced out of the fictional southern town of Crebillon, after forming a friendship with a young boy named Paul, whose dying mother is unable to protest against her son visiting such a woman. After Carrie has left town Paul runs away from his abusive father, and meets a girl named Lady who has run away from a burning trainwreck, not wanting to go back to the people she was with. Carrie comes back for Paul and ends up taking Paul and Lady to New York with her.

The Randolph family have a tradition of working in the British colonial service. Clive comes home from a mission in the Gold Coast of Africa accompanied by his wife Helen. He discovers his younger brother John, is not keen on following in his footsteps. John is then persuaded to try colonial service by his grandfather. He is accompanied by Clive who has been sent to investigate the source of a series of radio broadcasts that are sewing unrest throughout the world. These may be linked to Hugo Zurof, a man plotting to rule the world.

When her husband is accused of murder, an actress tries to prove his innocence.

Good-natured gambler Marty Black falls into ownership of a booking joint but soon falls on hard times. His one out is a marker for half-ownership in a young thoroughbred, which he quickly calls in. He discovers the other owner to be a young woman from an old horse racing family who wants to protect her colt almost as much as Marty wants to rush him into big races for a fast buck. While they clash, Marty soon comes to understand the human bond with the horses and what it means to be a thoroughbred.