Gertrudis and Armida are two young sisters with completely different personalities who learn to support each other after becoming orphans and being taken under the care of their aunt Luzmila, who denies them any kind of love. Between their innocence and their audacity, the two young women plan to escape, but everything goes wrong, they end up separated and thinking that the other one has died. It will take two decades for these two sisters to reunite.

A group of five American friends on the cusp of adulthood travel to Panama to relax and reconnect. They befriend a local woman in their hotel bar—and despite some ominous whispers—she goes against the specific instructions of her brother and brings the Americans on a daytrip into the pristine falls at the nearby jungle. What begins as an innocent outing to a picturesque waterfall quickly turns terrifying after she suddenly goes missing. As night closes in, the friends realize too late the truth behind the rumors—the legendary, blood-sucking Chupacabra is now stalking them.