Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Daisy, a gun-toting grumpy old battle-axe, eeking out her life in a tumbledown shack in the middle of nowhere. Into her life stumbles Simon, a mild-mannered accountant. Together, they form an uneasy alliance that is hilarious to watch. Gradually he helps her rediscover her zestful youth in return for stability in his troubled life.