The Five Brothers follows the Juthathep brothers in the 1960s, raised by their grandmothers after their parents’ tragic death. Born into nobility, they are expected to embody honor, protect the weak, and—most importantly—marry well. But their lives become more complicated when a sacred promise binds one of them to marry a lady of the Dhevaprom family, and breaking it would bring great dishonor.

One day, Primma finds herself pregnant with her boyfriend Panu. However, Panu has a bright future and is going abroad to study. Therefore, Primma decided to keep the fact of her pregnancy a secret and runs away to be a single mom. Gunnaree, is a working woman and works as a financial controller. She has always thought of having a baby and so decides to freeze her eggs while they are in optimal condition and wait for the perfect sperm. Sarinta has to survive with her strict politician husband, Poramet, who views societal image and opinion more than anything in the world.

Chittawan goes to jail because he was framed for killing his fiances' father. After getting out, he decides to take revenge on the people who are the cause behind him having to go to jail.

A 52-year-old teacher got dumped by her boyfriend just because she's old. She ended up doing a full-body plastic surgery that made her looked like 25-year-old girl. After that, many young men were all trying to woo her until she met Tum who is a table tennis player. Tum wants to achieve a gold medal and earn prize money to take care of his grandmother's sickness while himself got a health problem too. Age gap relationship has started from there. Inspired by a true story of SLE patients.

Mark, the gay CEO of an entertainment company, is killed and is given 100 days as a ghost to settle his unfinished business. Cin is a kind shy woman who lives a harsh life with her brother Sun and cruel stepmother and stepsister. Mark discovers he can possess Cin, and together they set out to help Mark's family and business, and solve the mystery of his death (with help from his brother Mate). Along the way, Mark helps Cin improve her own life and find love.

Ruthainak (Chalida Vijitvongthong) is the smart, resilient, sharp-tongued younger sister. Her older sister, Nunthaka (Selina Pearce), is beautiful, but spoiled and sheltered. In financial difficulties, the girls' father asks a member of the Hong Kong mafia, Lin Lang Sur (Tanin Manoonsilp), for a large loan. He pledges Nunthaka as collateral to secure the debt. Panicked when he is unable to repay the money, he flees with Nunthaka. When Ruthainak is taken to Hong Kong to confront the furious mafioso, she offers to work to pay off her family's debt. In the beginning, Ruthainak and Lin Lang Sur don't get along, but slowly the mob boss begins to fall for the clever girl.

The story is set in the 1970s, in a small Thai village. Paitoon is in love with Yupin, whose father has gambling issues. They planned on getting married but Pao, his mother, doesn't like Yupin and won't accept their relationship because of her father. While Paitoon is in monkhood, Pao forces Yupin to marry Praiwan, Paitoon's brother who's suffering from polio since childhood. From now on, Yupin is Paitoon's sister-in-law, but their love for each other has not gone away. Will they be able to overcome all obstacles and be together again?

Rasika is a modern girl who is self-confident and likes romantic novels, especially when it has time travel. One day, she buys the novel Dan Phromlikhit Rak and somehow finds herself as Karakade, the heroine in the novel. Karakade lives in 1923 and is the daughter of someone with high status. She meets the hero and they fell in love instantly. The story describes the journey they go through in order to fulfill their love even though she already has someone she is supposed to be engaged to.

Pang and Puen are twins who were separated. Pang is an actress in Thailand and Puen is a patissier in Australia, where she lives with her adopted family. Puen always felt like an outsider so when Feilan, her best friend tells her that she saw a lakorn with an actress just like her, she decides to go to Thailand and find out the truth. Pang's love interest is Kanlong, a businessman who liked her ever since he was young and Puen's love interest is Warat, an actor who initially tries to court Pang.