The Five Brothers follows the Juthathep brothers in the 1960s, raised by their grandmothers after their parents’ tragic death. Born into nobility, they are expected to embody honor, protect the weak, and—most importantly—marry well. But their lives become more complicated when a sacred promise binds one of them to marry a lady of the Dhevaprom family, and breaking it would bring great dishonor.

Three people with different backgrounds go on the run from the mafia, finding love and connection amid danger and survival.

Sakkarn is a man who mentally falls apart because the love of his life committed suicide. The night she jumped off the building, she landed on the windshield of his car. Devastated, Sakkarn isolates himself from the world and scares his family with his erratic behaviors. He is heartbroken and deeply depressed over the death of his fiancee, Aeuy. His mother is worried and asked advice from a longtime friend who has a daughter. Seeing that the only way to heal her son’s sorrowful state is to find him a new love, she arranges a marriage between Sakkarn and her friend’s daughter, Purimarn, the young woman who helps him regain his sanity by showering him with love and support.

Set in Suwanthani during the early Rattanakosin era and follows three slaves—Sang Thong, Mai Phlong, and Thong Bai—who work in the household of Khun Phra Bamroekrung. Sang Thong is a charming talker, Mai Phlong is quick-witted but not very bright, and Thong Bai is an inventor whose creations resemble things from 2025. Despite being close friends, they all fall for Jolie, a foreign missionary teaching English to Khun Phra Bamroekrung's children. When the groom is found shot dead at Khun Phra Bamroekrung's wedding, the three are suspected of murder. Faced with overwhelming evidence against them, they must escape and uncover the true killer.

Tinrat and Katleya have been in love for 3 years, but because of her ambition, Katleya decided to marry Tinrat's father. Many years have passed, Tinrat's father is now gone, and Katleya wants to get Tinrat back. On the other hand, Tinrat has a new girlfriend for a long time but he still can't forget Katleya. Kuat is Katleya's son, Tinrat's brother. He is gay but only his uncle Mai, Katleya's brother, knows about this. When Katleya learns about his being gay, she couldn't accept it, she wanted him to be as perfect as his brother. While being down, Kuat meets with Jomkwan, a rich lady who ran away from home because of family matters. They become very friendly and Jomkwan is pretending to be Kuat's girlfriend. They live together in Kuat's condo.

Kongpop manipulates Namnueng into marriage to gain control of her inheritance, but when his deception is exposed, he must confront the fallout as real feelings begin to surface.

Aom's a shopaholic who has gotten herself into debt for 400k dollars, one day she decides to runaway fearing that debt collectors might try to hunt her down and harm her. Her boss Lek and her are always fighting and have never gotten along but he offers to help pay her debt if she will pretend to be his girlfriend so his mother will stop trying to set him up.

Following the life of Pierra Vejjabul, one of the first Thai female doctors.