Preston Tylk is an ordinary guy living in Seattle. When he discovers that his beloved wife, Emily, is having an affair, he is devastated. Storming out of the house, he returns later only to find her brutally murdered.

Meet Zach. Nice guy. Terrible taste in women. They leave him, but they never forget him. He's heading into the next bad break-up when the newest fad in H2O drinks starts turning his ex girlfriends into zombies who have one idea - getting back together with Zach! Three friends must stop the Ex's and save the world.