In war-torn Japan, the Tokugawa Shogun, desperate to restore peace to his people, orders the assassination of the hostile warlords. A beautiful young woman is raised from birth with nine other orphans, to become an assassin. Her name is Azumi, the ultimate assassin.

A group of ruthless gangsters, an unknown woman and an escaped convict have met, in The Forest of Resurrection, the 444th portal to the other side. Their troubles start when those once killed and buried in the forest come back from the dead.

Tenshu is imprisoned and sentenced to death for murdering the men who raped his girlfriend. However, he manages to survive his execution and is presented with an option: face another execution attempt or subject himself to their bizarre and dangerous experiments.

A war rages on, its end unknown, covering the world in despair. At a military field hospital, a group of soldiers bring in one of their own, wounded by a large, vicious, bite-like wound, along with a large box. The soldiers are visibly shaken. Suddenly, an enigmatic man appears. As he starts to tell them the legend of the Lance of Longinus, their night of unimaginable terror begins.